Limited-Edition Power Infusing Concentrate

A potent antioxidant face serum with a lightweight formula that visibly reduces signs of aging, amplifies hydration and boosts radiance in 3 days*.

*Tested by 104 women.


Limited Edition




Item No. 0729238209435
    • Size:
    • 75mL
Add to cart options

Product Actions

Price: $140.00 now $140.00 ,


    • Size:
    • 75mL


Shiseido is pleased to offer the convenience of having your Shiseido favorites delivered to you automatically so you never have to worry about running out. Enjoy a Free 2-day shipping on your 1st order + 10% off future orders by simply selecting the desired delivery cycle when adding items to your cart. We'll send you a reminder email when your replenishment order is ready to be shipped. You may cancel at any time up to 24 hours before your next shipment. Standard shipping will be applied for US Territories and Military addresses. Please find our shipping policies here.


Read More
Free Shipping & Free Samples with Every Order


The culmination of 150 years of Japanese skincare innovation, Ultimune face serum delivers 2x skin‘s defenses** with ImuGenerationRED Technology™. Vital nutrients are fed to the skin, visibly reducing signs of aging, amplifying hydration, and boosting radiance in 3 days*. Now available in a refill size.


  • Reduces signs of aging
  • Improves hydration
  • Boosts radiance
  • Enhances the efficacy of other skincare products
  • Winner of 224 global beauty awards
  • Refill helps reduce plastic waste by up to 95% compared with a regular product
  • Dermatologist-tested. Non-comedogenic.
*Tested by 104 women.
**Based on the improvement of moisture-retention rate and transepidermal water loss.


  • In 3 days, skin becomes more radiant*
  • In 1 month, skin becomes more resilient and firm**
  • After 1 bottle, wrinkles are visibly reduced***
*Tested by 104 women.
**Tested by 115 women.
***Based on a 50mL bottle.

How to use

  • Use Ultimune after cleansing and softening skin, but before applying any other serums or moisturizers.
  • Pump twice onto your fingertips and smooth evenly over face and neck.
  • Use Ultimune twice daily, morning and night.
  • FOR REFILL: Save the pump and cap from your original bottle. Insert the pump into the refill, then close cap.

Key ingredients

  • FERMENTED ROSELLE EXTRACT: Increases skin’s capacity to hold water and prevents elastin degradation for plumper, smoother, and more radiant skin.
  • HEARTLEAF EXTRACT: An Eastern ancient herb that soothes skin and strengthens its protective barrier. Detoxifies skin while optimizing oxygenation.
  • REISHI MUSHROOM: Rich in antioxidants and polysaccharides, it hydrates and protects to visibly reduce signs of aging.
  • IRIS ROOT EXTRACT: Known to survive in extreme temperatures, this hardy plant is recognized for its vitality and moisturizing abilities.


Limited-Edition Power Infusing Concentrate